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Givlaari: Benefits, Reviews, Info, Side Effects!
Rx Details
Givlaari
Givosiran, ALN-AS1
Givosiran
Prescription
Medication
Drugs
Prescription Only
reduces levels of toxic porphyrin precursors, decreases frequency of acute hepatic porphyria attacks, improves quality of life for patients with acute hepatic porphyria, administered once a month, subcutaneous injection, specific treatment for acute hepatic porphyria
Abdominal Pain, Decreased Appetite, Dizziness, Fatigue, Fever, Headache, Increased Liver Enzymes, Injection Site Reactions, Nausea, Rash
Givlaari (givosiran) is a medication used to treat acute hepatic porphyria (AHP) in adults. The typical dosage of Givlaari is based on the patient’s body weight. The recommended dose is 2.5 mg/kg administered once monthly as a subcutaneous injection. It’s important for patients to follow their healthcare provider’s instructions regarding dosage and administration. Always consult with a healthcare professional for personalized medical advice.
Acute hepatic porphyria
Givlaari has a favorable safety profile.
No Interactions Reported
$5,000 – $10,000
$575,000

A Synopsis of

Givlaari

Givlaari is a breakthrough medication that has shown great promise in the treatment of acute hepatic porphyria (AHP). AHP is a rare genetic disorder that affects the liver’s ability to produce heme, a crucial component of hemoglobin. This can lead to a buildup of toxic substances in the body, causing severe abdominal pain, neurological symptoms, and potentially life-threatening attacks.

Givlaari works by targeting a specific enzyme in the heme production pathway, helping to reduce the buildup of toxic substances and prevent the onset of AHP attacks. Clinical trials have shown that Givlaari can significantly reduce the frequency and severity of attacks in patients with AHP, improving their quality of life and reducing the need for hospitalizations.

As with any medication, Givlaari may cause side effects in some patients. These can include injection site reactions, nausea, and fatigue. It is important to discuss any concerns or potential side effects with your healthcare provider before starting treatment with Givlaari.

It is important to note that Givlaari is not a cure for AHP, but it can help manage the symptoms and reduce the frequency of attacks. It is typically administered as a subcutaneous injection once a month, under the supervision of a healthcare provider.

If you or a loved one has been diagnosed with AHP, Givlaari may be a valuable treatment option to consider. Talk to your healthcare provider to see if Givlaari is right for you and to learn more about how it can help manage this rare and challenging condition.

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