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Andexxa: Benefits, Reviews, Info, Side Effects!
Rx Details
Andexxa
Andexanet alfa, Coagulation factor Xa (recombinant), PRT064445
Andexanet alfa
Prescription
Antidote
Drugs
Prescription Only
reversal of anticoagulation, treatment of life-threatening bleeding, rapid onset of action, specific for factor Xa inhibitors, reduces bleeding complications
Anxiety, Back Pain, Confusion, Constipation, Cough, Dizziness, Fatigue, Fever, Headache, Hypokalemia, Infusion-Related Reactions, Muscle Spasms, Nausea, Pneumonia, Rapid Heartbeat, Shortness Of Breath, Swelling Of Limbs, Urinary Tract Infections, Vomiting
Andexxa, also known as andexanet alfa, is a medication used to reverse the effects of certain anticoagulants, specifically factor Xa inhibitors like rivaroxaban and apixaban. The dosage of Andexxa can vary based on the specific anticoagulant involved and the timing of the last dose of that anticoagulant. Typically, Andexxa is administered as an intravenous bolus followed by a continuous infusion. The dosing regimen is generally categorized into two levels: 1. **Low Dose**: – Initial IV bolus of 400 mg at a rate of approximately 30 mg/min. – Followed by a continuous infusion of 4 mg/min for up to 120 minutes. 2. **High Dose**: – Initial IV bolus of 800 mg at a rate of approximately 30 mg/min. – Followed by a continuous infusion of 8 mg/min for up to 120 minutes. The choice between low and high dose depends on factors such as the specific factor Xa inhibitor involved, the dose of the anticoagulant, and the time since the last dose was taken. It is important for healthcare providers to follow specific guidelines and consider individual patient factors when determining the appropriate dosage. Always consult a healthcare professional for precise dosing information.
Andexxa is commonly used to treat, reverse the effects of anticoagulation from apixaban, reverse the effects of anticoagulation from rivaroxaban.
Andexxa has a favorable safety profile.
No Interactions Reported
$4,000 – $6,000
$24,000

A Synopsis of

Andexxa

Andexxa, also known as andexanet alfa, is a medication used to reverse the effects of certain blood thinners, specifically factor Xa inhibitors. These types of blood thinners are commonly prescribed to prevent blood clots in patients with conditions such as atrial fibrillation or deep vein thrombosis. However, in some cases, patients may experience severe bleeding while taking these medications, which can be life-threatening.

Andexxa works by binding to the factor Xa inhibitors in the bloodstream, effectively neutralizing their effects and allowing the blood to clot normally. This can be crucial in emergency situations where a patient is experiencing uncontrolled bleeding while on a factor Xa inhibitor.

It is important to note that Andexxa is not a first-line treatment for bleeding associated with factor Xa inhibitors, and should only be used in certain situations under the guidance of a healthcare provider. Additionally, Andexxa is not effective in reversing the effects of other types of blood thinners, such as warfarin.

As with any medication, Andexxa may cause side effects in some patients. These can include headache, nausea, and vomiting. It is important to discuss any potential risks and benefits of Andexxa with your healthcare provider before starting treatment.

Overall, Andexxa can be a life-saving medication for patients who experience severe bleeding while taking factor Xa inhibitors. If you have any questions or concerns about Andexxa or its use, do not hesitate to speak with your healthcare provider for more information.

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